REGULATOR TCELL

Regulator T-cells control the development of effector T-cells. Two types exist: T-helper cells (CD41 cells) and T-suppressor cells. There are three subsets of T-helper cells: TH₁, TH₂, and TH₀. TH₁cells produce IL-2, IFN-g, and TNF-b. They effect cell-mediated immunity and are responsible for delayed-type hypersensitivity reactions and macrophage activation. TH₂cells produce IL-4, IL-5, IL-6, IL-10, IL-13. They are helpers for B-cell antibody responses and humoral immunity; they also support IgE responses and eosinophilia. TH₀cells exhibit an unrestricted cytokine profile.